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The target audience for this guideline includes all clinicians, and the target patient population includes adults with major depressive disorder.

This guideline grades the evidence and recommendations using ACP's clinical practice guidelines grading system.

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Relapse is defined as the return of depressive symptoms during the acute or continuation phases and is therefore considered part of the same depressive episode, whereas recurrence is defined as the return of depressive symptoms during the maintenance phase and is considered a new, distinct episode.Response to treatment (typically defined as ≥50% reduction in measured severity) can be quantified using various tools, such as the Patient Health Questionnaire-9 (PHQ-9) (7) or the Hamilton Depression Rating Scale (HAM-D) (8).Even though Daniel wants nothing to do with Luce–and goes out of his way to make that very clear–she can’t let it go. even if it kills her.“Sexy and fascinating and scary . Mysterious and aloof, he captures Luce Price’s attention from the moment she sees him on her first day at the Sword & Cross boarding school in sultry Savannah, Georgia. Dangerously exciting and darkly romantic, Fallen by Lauren Kate is a page turning thriller and the ultimate love story. Cast The first book in the worldwide bestselling FALLEN series is soon to be a motion picture! In the beginning, I’m not sure I knew I was starting down any of those twisted paths—paths that now seem so familiar to me that they are downright comforting. Drawn to him like a moth to a flame, she has to find out what Daniel is so desperate to keep secret . He’s the one bright spot in a place where cell phones are forbidden, the other students are all screw-ups, and security cameras watch every move. There’s something achingly familiar about Daniel Grigori. #1 New York Times bestseller A USA Today bestseller One of NPR.com’s 100 Best-Ever Teen Novels More than 3 million series copies in print! is so well crafted that readers can easily picture Luce walking among the marshes and crumbling buildings.”—Kirkus Reviews “A tantalizing, atmospheric Gothic romance, Fallen is well worth picking up.”—New York Times bestselling author Melissa Marr People ask me: Why angels? In the beginning, I’m not sure I knew I was starting down any of those twisted paths—paths that now seem so familiar to me that they are downright comforting.

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